HCPThink  

Keywords

Suggestions

Reference

What's New

          Dupilumab Treatment improves QoL in Adult Patients with Moderate-to-Severe Atopic Dermatitis

          26
          Print
          derm.skin repair

          In a phase II trial, dupilumabsignificantly improved clinical signs and symptoms in adults with moderate-to-severe atopic dermatitis (AD). Dupilumab is a human anti-interleukin-4 receptor α monoclonal antibody.

          Recently German researchers evaluated health-related quality of life (HRQoL) and correlation of HRQoL with secondary clinical and patient-reported outcomes in a subset of patients from the phase 2a study that was previously conducted. They randomized patients to 300 mg QW SC dupilumab or placebo for 12 weeks. The QoL Index for AD (QoLIAD) score (exploratory outcome) and its correlation with efficacy outcomes (EASI; SCORAD; VAS scores for sleep and pruritus were assessed in 64 adults with moderate-to-severe AD.

           

          Mean QoLIAD scores at baseline were 13.3 (±1.34) and 11.3 (±1.09) for the placebo and dupilumab group, respectively. Dupilumab significantly improved QoLIAD score after 12 weeks of treatment vs. placebo. LS mean % difference from baseline vs. placebo in QoLIAD score (±SE) was −52.0 (±11.43; P<0.0001). QoLIAD scores significantly correlated with changes in efficacy outcomes, including EASI (r=0.4355), 5-dimensional pruritus (r=0.4937), pruritus NRS (r=0.4064), total SCORAD (r=0.5559), and SCORAD VAS scores for sleep (r=0.4681) and pruritus (r=0.5400); all P<0.05.

          The findings thus show dupilumabto have an improvement in QoLIAD scores in adults with AD and to be significantly associated with improvements in study outcomes. These findings should make it easy to carry forward a largescale phase III study.

          Ref: http://onlinelibrary.wiley.com/doi/10.1111/bjd.15905/full


          Location :
          Source : Link

          27 total views, 1 views today

          TwitterFacebookGoogle+LinkedIn
          27

          Views

          Leave a Reply

          Popular News

          Chat []

          Login

          Lost your password?

          VERIFIED & SECURED SSL VERIFIED & SECURED SSL: Secure Socket Layer