Metabolic Impact of High Fructose Corn Syrup Restriction in Obese Children
Overall, 80% children adhered to the study program, reporting a decrease in high fructose corn syrup consumption from 110±38.6 g/day to 11.4±12.0 g/day. Significant decreases in caloric intake (2384±568 kcal/day to 1757±387 kcal/day) and carbohydrate consumption (302±80.4 to 203±56.0 g/day) were also noted. There were no changes in BMI or diastolic BP and markers of insulin resistance remained the same. Although 73.1% participants presented with fatty liver at the beginning of the study, a decrease in liver steatosis was noted following intervention.
There was fructose restriction associated with diminution of triglyceride levels and an important diminution of liver steatosis. The results did not show any changes of body weight or insulin resistance that may be explained by adaptive changes in metabolic expenditure.
Since study involved the pediatric population, findings may not be generalizable to entire population.