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          Vitamin D Insensitivity in the Rheumatoid Joint

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          Vitamin D has several positive health effects. Researchers from Univ/ of Birmingham however are of the opinion, based on a study findings that, while Vitamin D may be effective at preventing the onset of inflammation, it is less effective once inflammatory disease is established. This is true in case of rheumatoid arthritis because once the condition is established, it leads to vitamin D insensitivity.

          Another key finding was that the impact of vitamin D on inflammatory disease cannot be predicted using cells from healthy individuals or even from the blood of patients with inflammation as cells from the diseased tissue behave in a very different way.

           

          1,25-dihydroxyvitaminD3 (1,25(OH)2D3) is known to have potent anti-inflammatory effects, including suppression of IL-17 + and IFNγ+ T cells. Researchers studied cells from paired peripheral blood and synovial fluid (SF) samples in patients with active RA and assessed cellular responses to the active form of vitamin D.Overall theyfound that cells taken from the joints of RA patients were much less sensitive to active vitamin D. 1,25(OH)2D3 had significantly less suppressive effect on Th17 cells (IL-17+IFNγ-) and Th17.1 cells (IL-17+IFNγ+) from SF compared to those from blood, and had no effect on SF CD4+ or CD8+ IFNγ+ T cell frequencies.

          According to researchers, perhaps higher doses of vitamin D may be needed to overcome the vitamin D insensitivity within the joint.

          Ref: http://rheumnow.com/content/vitamin-d-insensitivity-rheumatoid-joint


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